Genomic Research Laboratory
Group of Prof. J. Schrenzel
Service of Infectious Diseases
Geneva University Hospitals (HUG)
CH-1211 Geneva 4, Switzerland

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Application of proteomic strategies to characterise S. aureus virulence and its resistance to antibiotics.

Research program rewarded by the 2007 Viollier Award.

S. aureus can produce at least thousands of different proteins; more products than genes. To pinpoint factors of virulence and understand mechanisms of resistance to some antibiotics, it is imperative to look at the proteins which are operative as functional components. Discovery of differences in protein expression will generate targets for further biological analysis.

Two specific objectives of our current research are to:

  1. build a protein expression index for various S. aureus strains;
  2. perform comparative analysis of the various strains under different biological growth conditions.

To achieve this, various technologies are employed for differential display analysis and mass spectrometry for identification of proteins. The use of various technologies allows one to capture molecular diversity in S. aureus without preconceived ideas about which information will be most valuable to monitor, or which technologies will have the greatest impact.

We have recently set-up the stage for correlating transcriptomic and proteomic data (Scherl et al., J Microbiol Methods. 2005), and streamlined the process of peptide identification (Scherl et al., Proteomics. 2004).

Research Projects
  qMRSA: Detection of MRSA
  MagRSA: Automated Diagnosis of MRSA
  S. aureus biofilms
  S. aureus Intracellular Survival
  S. aureus Proteomics
  NRP-49 Projects: Antimicrobial Resistance
  GESNOMA: Noma disease
  MLVA: S. aureus Genotyping
  MIF Knock-Out Mouse Macrophages
  Patho-adaptation of S. aureus
  Phylogenetic Microarray
  High Throughput Sequencing

Revised Mar 26, 2008 - © 2003-2022 Genomic Research Laboratory, Geneva